Title : Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.

Pub. Date : 2019 Jan 31

PMID : 30401703






2 Functional Relationships(s)
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1 Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML-induced NOX2-derived superoxide. Superoxides cytochrome b-245, beta polypeptide Mus musculus
2 Together, these data identify leukemia-generated NOX2-derived superoxide as a driver of protumoral p16INK4a-dependent senescence in BM stromal cells. Superoxides cytochrome b-245, beta polypeptide Mus musculus