Title : Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.

Pub. Date : 2019 Jan 1

PMID : 30396105






1 Functional Relationships(s)
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1 The most effective Tdp1 inhibitor, 20d, was ton-toxic and increased the effect of topotecan both in vitro and in vivo in the Lewis lung carcinoma model. Topotecan tyrosyl-DNA phosphodiesterase 1 Mus musculus