Title : Modulating Survivin as a Radioresistant Factor, Caspase-3, and Apoptosis by Omega-3 Docosahexaenoic Acid Sensitizes Mutant-p53 Colorectal Cancer Cells to γ-Irradiation.

Pub. Date : 2018 Nov

PMID : 30395490






2 Functional Relationships(s)
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1 Pretreatment of 5 x 105 HT-29 cells per well with 100-muM DHA for 4-h followed by 2- or 10-Gy of irradiation resulted in 53% and 86% decreases in cell numbers, 2- and 5.1-fold activation in caspase-3 followed by 66% and 60% decreases in survivin mRNA levels respectively. Docosahexaenoic Acids caspase 3 Homo sapiens
2 DHA decreases survivin expression and induces caspase-3 activation irrespective of p53 status. Docosahexaenoic Acids caspase 3 Homo sapiens