Title : Rapid peroxynitrite reduction by human peroxiredoxin 3: Implications for the fate of oxidants in mitochondria.

Pub. Date : 2019 Jan

PMID : 30391677






1 Functional Relationships(s)
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1 Herein, we demonstrate the human peroxiredoxin 3 reduces peroxynitrite with a rate constant of 1 x 107 M-1 s-1 at pH 7.8 and 25 C. Reaction with hydroperoxides caused biphasic changes in the intrinsic fluorescence of peroxiredoxin 3: the first phase corresponded to the peroxidatic cysteine oxidation to sulfenic acid. Cysteine peroxiredoxin 3 Homo sapiens