Title : 3-Dehydroandrographolide protects against lipopolysaccharide-induced inflammation through the cholinergic anti-inflammatory pathway.

Pub. Date : 2018 Dec

PMID : 30391477






2 Functional Relationships(s)
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1 3-DA attenuated the release of pro-inflammatory cytokines IL-6 and TNF-alpha, inhibited the degradation and phosphorylation of IkappaBalpha, and suppressed the nuclear translocation of NF-kappaB p65 as well as the phosphorylation of Akt at Ser473 in LPS-stimulated RAW 264.7 macrophage cells. 3-da thymoma viral proto-oncogene 1 Mus musculus
2 Besides, 3-DA significantly inhibited inflammation in LPS-induced ALI mice, which was associated with the decrease of lung water content and inflammatory cytokines, the inhibition of neutrophil and macrophage infiltration, and activation of the NF-kappaB/Akt signaling pathway. 3-da thymoma viral proto-oncogene 1 Mus musculus