Pub. Date : 2018 Dec
PMID : 30391477
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 3-DA attenuated the release of pro-inflammatory cytokines IL-6 and TNF-alpha, inhibited the degradation and phosphorylation of IkappaBalpha, and suppressed the nuclear translocation of NF-kappaB p65 as well as the phosphorylation of Akt at Ser473 in LPS-stimulated RAW 264.7 macrophage cells. | 3-da | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Besides, 3-DA significantly inhibited inflammation in LPS-induced ALI mice, which was associated with the decrease of lung water content and inflammatory cytokines, the inhibition of neutrophil and macrophage infiltration, and activation of the NF-kappaB/Akt signaling pathway. | 3-da | thymoma viral proto-oncogene 1 | Mus musculus |