Title : Beta-endorphin stimulates human polymorphonuclear leukocyte superoxide production via a stereoselective opiate receptor.

Pub. Date : 1987 Aug

PMID : 3039121






1 Functional Relationships(s)
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1 beta-END was found to stimulate O2- release at concentrations from 10(-14) to 10(-8) M; the peak response occurred at 10(-12) M. A microassay based on the horseradish peroxidase-mediated oxidation of phenol red was used to demonstrate the production of hydrogen peroxide H2O2, by beta-END at 10(-12) M. The accumulation of H2O2 was reduced by the inhibitor, nitroprusside, and by the converting enzyme, catalase. Nitroprusside proopiomelanocortin Homo sapiens