Pub. Date : 2019 Mar
PMID : 30387162
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TLR2 protects cisplatin-induced acute kidney injury associated with autophagy via PI3K/Akt signaling pathway. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Therefore, we propose that cisplatin might activate TLR2, which subsequently phosphorylates PI3K/Akt, leading to enhanced autophagy of renal tubular epithelial cells and protecting cisplatin-induced AKI. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Mechanistically, TLR2 inhibited autophagy via activating PI3K/Akt signaling pathway in renal tubular epithelial cells after the cisplatin treatment. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | Take together, these results suggest that TLR2 may protect cisplatin-induced AKI by activating autophagy via PI3K/Akt signaling pathway. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |