Title : Installation of Multiple Aryl Ether Crosslinks onto Non-Native Substrate Peptides by the Vancomycin OxyB.

Pub. Date : 2018 Jun 28

PMID : 30386000






1 Functional Relationships(s)
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1 Herein, we report that OxyBvan, the P450 enzyme that installs the first crosslink in vancomycin biosynthesis, is capable of catalyzing the formation of its conventional C-O-D bis-aryl ether bond in non-natural substrates and, furthermore, the formation of a second, novel linkage when D-Trp is incorporated at position 6. Vancomycin small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens