Pub. Date : 2018
PMID : 30381640
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Second, we found that TNF-alpha induces IRS-1 phosphorylation at serine residues 636/639 and inhibits the tyrosine phosphorylation of IRS-1 through the increase in both extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) phosphorylation. | Serine | tumor necrosis factor | Homo sapiens |
2 | Interestingly, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, an AMP-activated protein kinase activator, suppresses TNF-alpha-induced IRS-1 serine phosphorylation at 636/639 and the phosphorylation of ERK by enhancing interactions between ERK and dual-specificity phosphatase-9. | Serine | tumor necrosis factor | Homo sapiens |