Title : Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.

Pub. Date : 2018 Nov 13

PMID : 30381458






1 Functional Relationships(s)
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1 Here, using Yersinia pseudotuberculosis in corroboration with costimulation of lipopolysaccharide and (5Z)-7-Oxozeaenol, a small-molecule inhibitor of TAK1, we show that caspase-8 activation during TAK1 inhibition results in cleavage of both gasdermin D (GSDMD) and gasdermin E (GSDME) in murine macrophages, resulting in pyroptosis. 5-7-oxo-zeaenol caspase 8 Homo sapiens