Pub. Date : 2019 Feb
PMID : 30381441
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: The major mode of metabolism of nicotine is by hydroxylation via cytochrome P450 (CYP) 2A6, but it can also undergo glucuronidation by UDP-glucuronosyltransferases and oxidation by flavin monooxygenases (FMO). | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | CONCLUSIONS: These data indicate that increases in nicotine-N"-oxidation occur in subjects with deficient CYP2A6 activity, and that several FMO enzymes are active in nicotine-N"-oxidation. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | IMPACT: Several common missense FMO variants are associated with altered enzyme activity against nicotine and may play an important role in nicotine metabolism in low-CYP2A6 activity subjects. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 4 | IMPACT: Several common missense FMO variants are associated with altered enzyme activity against nicotine and may play an important role in nicotine metabolism in low-CYP2A6 activity subjects. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |