Title : Curcumin restores hepatic epigenetic changes in propylthiouracil(PTU)Induced hypothyroid male rats: A study on DNMTs, MBDs, GADD45a, C/EBP-β and PCNA.

Pub. Date : 2019 Jan

PMID : 30367912






1 Functional Relationships(s)
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1 In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta. Propylthiouracil CCAAT/enhancer binding protein beta Rattus norvegicus