Pub. Date : 2018 Oct 25
PMID : 30366412
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isotopic profiling of fatty acids revealed that higher lipid anabolism in IDH1 mutant cells corroborated with an increase in lipogenesis fluxes. | Fatty Acids | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Therefore, we have determined that lipid anabolism is strongly reprogrammed in IDH1 mutant AML cells with a crucial dysregulation of fatty acid metabolism and fluxes, both being mediated by 2-HG (2-Hydroxyglutarate) production. | Fatty Acids | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |