Title : CUDC-907 blocks multiple pro-survival signals and abrogates microenvironment protection in CLL.

Pub. Date : 2019 Jan

PMID : 30353642






1 Functional Relationships(s)
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1 CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. CUDC-907 AKT serine/threonine kinase 1 Homo sapiens