Pub. Date : 2019 Mar
PMID : 30350722
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | S-nitrosylation of Src by NR2B-nNOS signal causes Src activation and NR2B tyrosine phosphorylation in levodopa-induced dyskinetic rat model. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 2 | N-methyl-D-aspartate receptor (NMDAR) subunit NR2B tyrosine phosphorylation mediated by Src family protein tyrosine kinases is closely associated with dyskinesia. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 3 | Coinstantaneously, the S-nitrosylation (SNO-Src) and autophosphorylation (p-Src) of Src and NR2B tyrosine phosphorylation were upregulated in dyskinetic rat model. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 4 | Coinstantaneously, the S-nitrosylation (SNO-Src) and autophosphorylation (p-Src) of Src and NR2B tyrosine phosphorylation were upregulated in dyskinetic rat model. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 5 | Taken together, the S-nitrosylation of Src is caused by nNOS/NO signal, which is overactivated via Ca2+ influx dependent on NR2B/NMDAR, and subsequently facilitates Src auto-tyrosine phosphorylation and further phosphorylates NR2B. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 6 | Taken together, the S-nitrosylation of Src is caused by nNOS/NO signal, which is overactivated via Ca2+ influx dependent on NR2B/NMDAR, and subsequently facilitates Src auto-tyrosine phosphorylation and further phosphorylates NR2B. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 7 | The "NR2B/NMDAR-nNOS/NO-SNO-Src-p-Src-NR2B/NMDAR" signaling cycle may be the molecular basis of NR2B tyrosine phosphorylation upward positive feedback, which demonstrates the possibility as one latent target for dyskinesia therapy. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 8 | The "NR2B/NMDAR-nNOS/NO-SNO-Src-p-Src-NR2B/NMDAR" signaling cycle may be the molecular basis of NR2B tyrosine phosphorylation upward positive feedback, which demonstrates the possibility as one latent target for dyskinesia therapy. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |