Pub. Date : 2018 Nov 14
PMID : 30346792
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nanothermometry Reveals Calcium-Induced Remodeling of Myosin. | Calcium | myosin heavy chain 14 | Homo sapiens |
| 2 | A 10, 000-fold higher calcium in the sarcoplasmic reticulum (SR) of muscle suggests elevated calcium levels near active calcium channels at the SR membrane and the impact of localized high calcium on the structure-function of the motor protein myosin. | Calcium | myosin heavy chain 14 | Homo sapiens |
| 3 | In the current study, combined quantum dot (QD)-based nanothermometry and circular dichroism (CD) spectroscopy enabled detection of previously unknown enthalpy changes and associated structural remodeling of myosin, impacting its function following exposure to elevated calcium. | Calcium | myosin heavy chain 14 | Homo sapiens |
| 4 | Cadmium telluride QDs adhere to myosin, function as thermal sensors, and reveal that exposure of myosin to calcium is exothermic, resulting in lowering of enthalpy, a decrease in alpha helical content measured using CD spectroscopy, and the consequent increase in motor efficiency. | Calcium | myosin heavy chain 14 | Homo sapiens |
| 5 | Isolated muscle fibers subjected to elevated levels of calcium further demonstrate fiber lengthening and decreased motility of actin filaments on myosin-functionalized substrates. | Calcium | myosin heavy chain 14 | Homo sapiens |