Pub. Date : 2019 Jan
PMID : 30342367
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of hepatic miR-34a by perfluorooctanoic acid regulates metabolism-related genes in mice. | perfluorooctanoic acid | microRNA 34a | Mus musculus |
| 2 | We found that PFOA exposure (5 mg/kg/d PFOA for 28 d) resulted in a significant increase of miR-34a in the livers of mice but had no effect on either miR-34b or miR-34c. | perfluorooctanoic acid | microRNA 34a | Mus musculus |
| 3 | We found that PFOA exposure (5 mg/kg/d PFOA for 28 d) resulted in a significant increase of miR-34a in the livers of mice but had no effect on either miR-34b or miR-34c. | perfluorooctanoic acid | microRNA 34a | Mus musculus |
| 4 | Compared with the corresponding untreated control, significant increases in liver weight as well as serum alanine transaminase, aspartate aminotransferase, and cholinesterase levels were observed in miR-34a-/- and wild-type mice after PFOA exposure. | perfluorooctanoic acid | microRNA 34a | Mus musculus |
| 5 | With or without PFOA treatment, relatively fewer genes were altered in miR-34a-/- livers compared to wild-type livers. | perfluorooctanoic acid | microRNA 34a | Mus musculus |
| 6 | Therefore, the increase in acetylated P53 may have activated the transcription of miR-34a in mouse livers after PFOA treatment. | perfluorooctanoic acid | microRNA 34a | Mus musculus |