Title : Effect of oral morphine and naloxone on pituitary-adrenal response in man induced by human corticotropin-releasing hormone.

Pub. Date : 1987 Apr

PMID : 3033966






1 Functional Relationships(s)
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1 Oral morphine not only suppressed basal hormone levels (P less than 0.02), but also the peak response to hCRH compared with placebo (cortisol: 270 +/- 50 vs 559 +/- 80 nmol/l; ACTH: 5.1 +/- 1.5 vs 13.1 +/- 2.7 pmol/l; ir beta-endorphin: 48.5 +/- 8.7 vs 88 +/- 14 pmol/l; mean +/- SEM, P less than 0.02). Morphine proopiomelanocortin Homo sapiens