Pub. Date : 2018 Oct 18
PMID : 30337733
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To determine the effect of metformin and adiponectin on the proliferation of EC cells and the relationship between metformin and adiponectin. | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 2 | qRT-PCR and Western blot were used to detect the effect of different concentrations of metformin on the changes of adiponectin receptors (AdipoR1 and AdipoR2) of the EC cells both in mRNA and protein level and the role of compound C, an adenosine monophosphate-activated protein kinase (AMPK) inhibitor, on the above effects. | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 3 | Besides, metformin can increase adiponectin receptors expressions of EC cells both in mRNA and protein levels and this effect is accomplished by the activation of AMPK signaling pathway. | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |