Title : Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls.

Pub. Date : 2019 Feb

PMID : 30336275






2 Functional Relationships(s)
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1 In contrast, SPHK1, S1P3 and S1P4 mRNA expression levels were upregulated by 1,25(OH)2D3 treatment compared to the respective controls. Calcitriol sphingosine kinase 1 Homo sapiens
2 Overall, our results demonstrate for the first time that 1,25(OH)2D3 treatment can influence S1P receptor and SPHK expression and S1P levels in primary monocytes of both HC and subjects with T2D. Calcitriol sphingosine kinase 1 Homo sapiens