Pub. Date : 2018 Nov
PMID : 30333878
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibited the Akt and extracellular signal-regulated kinase (ERK)1/2 pathways in A549 cells and activated the p38 MAPK and c-Jun N-terminal kinase (JNK) pathways. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, inhibitors of p38 MAPK and JNK did not affect the effect of metformin on Nrf2, while inhibitors of Akt and ERK1/2 dose-dependently enhanced the inhibitory effects of metformin in A549 cells. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In conclusion, metformin inhibits the phosphoinositide-3 kinase/Akt and ERK1/2 signaling pathways in A549 cells to reduce the expression of Nrf2, GSTA1 and ABCC1. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |