Title : Heparin modulation of the neurotropic effects of acidic and basic fibroblast growth factors and nerve growth factor on PC12 cells.

Pub. Date : 1987 Apr

PMID : 3032991






3 Functional Relationships(s)
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1 While the neurotropic activities of aFGF and NGF are potentiated by heparin, that of bFGF is both partially inhibited or stimulated, depending upon the concentration of bFGF. Heparin fibroblast growth factor 1 Rattus norvegicus
2 Heparin blocked the binding of bFGF to the receptor but had only a small inhibitory effect on the binding of aFGF to the receptor. Heparin fibroblast growth factor 1 Rattus norvegicus
3 The stimulatory effects of heparin on the neurotropic activity of aFGF, bFGF, and NGF may occur through a site not associated with the respective cellular receptor for the growth factors. Heparin fibroblast growth factor 1 Rattus norvegicus