Pub. Date : 2018
PMID : 30317243
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells. | Glucose | vascular endothelial growth factor C | Homo sapiens |
| 2 | Therefore, we propose that high glucose promotes VEGF-C expression through LPA signaling in PCa cells. | Glucose | vascular endothelial growth factor C | Homo sapiens |
| 3 | METHODS: Pharmacological inhibitors and siRNAs were utilized to investigate the molecular mechanism of high glucose-induced VEGF-C expression. | Glucose | vascular endothelial growth factor C | Homo sapiens |
| 4 | RESULTS: We demonstrated that the expressions of VEGF-C, ATX, and calreticulin were increased upon high glucose treatments in PC-3 cells. | Glucose | vascular endothelial growth factor C | Homo sapiens |
| 5 | Moreover, high glucose-induced VEGF-C expression was mediated through the LPA1/3, PLC, Akt, ROS and LEDGF-dependent pathways. | Glucose | vascular endothelial growth factor C | Homo sapiens |