Title : Extended-release morphine sulfate and naltrexone hydrochloride (EMBEDA): naltrexone-associated withdrawal and abuse-related effects in patients with chronic pain and recreational opioid users.

Pub. Date : 2019 Mar

PMID : 30293449






4 Functional Relationships(s)
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1 Plasma naltrexone concentrations of MSN-treated individuals were summarized. Naltrexone moesin Homo sapiens
2 In >=89% of plasma naltrexone concentration samples from patients who took MSN (n = 166), naltrexone was below the limit of quantification (4.0 pg/mL). Naltrexone moesin Homo sapiens
3 CONCLUSIONS: When taken intact as directed, naltrexone in MSN does not precipitate withdrawal. Naltrexone moesin Homo sapiens
4 However, when MSN is crushed, naltrexone mitigates, but does not eliminate, the euphorigenic effects of crushed morphine sulfate. Naltrexone moesin Homo sapiens