Title : EGR1 is essential for deoxynivalenol-induced G2/M cell cycle arrest in HepG2 cells via the ATF3ΔZip2a/2b-EGR1-p21 pathway.

Pub. Date : 2018 Dec 15

PMID : 30286430






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ATF3DeltaZip2a/2b, which is a DNA binding domain truncated isoform of ATF3, was upregulated by DON. deoxynivalenol activating transcription factor 3 Homo sapiens
2 H3K9ac and H3K27ac were enriched at the promoter region of ATF3 following the DON treatment, and the knocking down of the genes responsible for H3K9ac and H3K27ac abolished the upregulation of ATF3 by DON. deoxynivalenol activating transcription factor 3 Homo sapiens
3 H3K9ac and H3K27ac were enriched at the promoter region of ATF3 following the DON treatment, and the knocking down of the genes responsible for H3K9ac and H3K27ac abolished the upregulation of ATF3 by DON. deoxynivalenol activating transcription factor 3 Homo sapiens
4 H3K9ac and H3K27ac were enriched at the promoter region of ATF3 following the DON treatment, and the knocking down of the genes responsible for H3K9ac and H3K27ac abolished the upregulation of ATF3 by DON. deoxynivalenol activating transcription factor 3 Homo sapiens
5 H3K9ac and H3K27ac were enriched at the promoter region of ATF3 following the DON treatment, and the knocking down of the genes responsible for H3K9ac and H3K27ac abolished the upregulation of ATF3 by DON. deoxynivalenol activating transcription factor 3 Homo sapiens