Pub. Date : 2019 May
PMID : 30284230
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydrogen peroxide-induced mitophagy contributes to laryngeal cancer cells survival via the upregulation of FUNDC1. | Hydrogen Peroxide | FUN14 domain containing 1 | Homo sapiens |
| 2 | Hydrogen peroxide significantly induced the elevation of FUNDC1, a mitophagic factor, in a time- and dose-dependent manner in laryngeal cancer cells, which was dependent on ERK signal activation. | Hydrogen Peroxide | FUN14 domain containing 1 | Homo sapiens |
| 3 | Knockdown of FUNDC1 by the siRNA attenuated the survival of laryngeal cancer cells under hydrogen peroxide stimulation. | Hydrogen Peroxide | FUN14 domain containing 1 | Homo sapiens |
| 4 | Moreover, the elevated FUNDC1 was required for the occurrence of mitophagy under hydrogen peroxide stimulation, which was identified by transmission electron microscopy, the alterations of mitochondrial permeability transition and the specific mitochondrial protein, hsp60. | Hydrogen Peroxide | FUN14 domain containing 1 | Homo sapiens |
| 5 | CONCLUSIONS: Hydrogen peroxide upregulated the expression of FUNDC1 through the activation of ERK1/2 signal to trigger a mitophagic response, giving laryngeal cancer cells a befit for survival. | Hydrogen Peroxide | FUN14 domain containing 1 | Homo sapiens |