Pub. Date : 2018 Dec
PMID : 30272364
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin suppresses hypoxia-induced migration via the HIF-1alpha/VEGF pathway in gallbladder cancer in vitro and in vivo. | Metformin | vascular endothelial growth factor A | Homo sapiens |
| 2 | Further experiments demonstrated that metformin inhibited hypoxia-induced migration via HIF-1alpha/VEGF in vitro. | Metformin | vascular endothelial growth factor A | Homo sapiens |
| 3 | In addition, metformin suppressed GBC growth and downregulated the expression of HIF-1alpha and VEGF in a GBC-SD cell xenograft model. | Metformin | vascular endothelial growth factor A | Homo sapiens |
| 4 | Taken together, these results suggest that HIF-1alpha may contribute to tumor migration via the overexpression of VEGF in GBC, while metformin is able to inhibit tumor migration by targeting the HIF-1alpha/VEGF pathway. | Metformin | vascular endothelial growth factor A | Homo sapiens |