Title : Metformin suppresses hypoxia‑induced migration via the HIF‑1α/VEGF pathway in gallbladder cancer in vitro and in vivo.

Pub. Date : 2018 Dec

PMID : 30272364






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Metformin suppresses hypoxia-induced migration via the HIF-1alpha/VEGF pathway in gallbladder cancer in vitro and in vivo. Metformin vascular endothelial growth factor A Homo sapiens
2 Further experiments demonstrated that metformin inhibited hypoxia-induced migration via HIF-1alpha/VEGF in vitro. Metformin vascular endothelial growth factor A Homo sapiens
3 In addition, metformin suppressed GBC growth and downregulated the expression of HIF-1alpha and VEGF in a GBC-SD cell xenograft model. Metformin vascular endothelial growth factor A Homo sapiens
4 Taken together, these results suggest that HIF-1alpha may contribute to tumor migration via the overexpression of VEGF in GBC, while metformin is able to inhibit tumor migration by targeting the HIF-1alpha/VEGF pathway. Metformin vascular endothelial growth factor A Homo sapiens