Pub. Date : 2019 Feb 1
PMID : 30272249
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine Promotes Human Papillomavirus (HPV)-Immortalized Cervical Epithelial Cells (H8) Proliferation by Activating RPS27a-Mdm2-P53 Pathway In Vitro. | Nicotine | ribosomal protein S27a | Homo sapiens |
| 2 | In addition, reduction of RPS27a expression in nicotine treatment H8 cells up-regulated phosphorylation of Mdm2 at serine residue 166, followed by facilitating Mdm2-mediated ubiquitination of P53. | Nicotine | ribosomal protein S27a | Homo sapiens |
| 3 | Simply put, these findings suggest that nicotine promotes H8 cell lines proliferation by activating RPS27a-Mdm2-P53 pathway in vitro. | Nicotine | ribosomal protein S27a | Homo sapiens |