Title : Modification of Cysteine 179 in IKKβ by Ursolic Acid Inhibits Titanium-Wear-Particle-Induced Inflammation, Osteoclastogenesis, and Hydroxylapatite Resorption.

Pub. Date : 2018 Nov 5

PMID : 30265541






1 Functional Relationships(s)
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1 As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10. ursolic acid mitochondrially encoded cytochrome c oxidase II Homo sapiens