Pub. Date : 2018 Nov 19
PMID : 30265530
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Moreover, cyadox (2 muM) activated the Akt and increased the EGF, cyclin D1, and FOXO1 expression levels. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Additionally, the activated P53 pathway, hyperactivated Akt, and apoptosis were found in L02 cells after incubation with 100 muM cyadox. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Our data demonstrated that Akt promoted cell survival when it was mildly activated by cyadox at 2 muM, and Akt leads to apoptosis when it was severely activated by cyadox at 100 muM. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | Our data demonstrated that Akt promoted cell survival when it was mildly activated by cyadox at 2 muM, and Akt leads to apoptosis when it was severely activated by cyadox at 100 muM. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | Our data demonstrated that Akt promoted cell survival when it was mildly activated by cyadox at 2 muM, and Akt leads to apoptosis when it was severely activated by cyadox at 100 muM. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |
| 8 | Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |
| 9 | Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |
| 10 | Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox. | cyadox | AKT serine/threonine kinase 1 | Homo sapiens |