Title : Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.

Pub. Date : 2018 Nov

PMID : 30264400






2 Functional Relationships(s)
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1 GR EPI-EC silencing or inhibition led to (1) increased Pphenytoin BBB permeability as compared to control; (2) decreased CYP function, indirectly evaluated by resorufin formation; (3) improved OXC bioavailability with increased abluminal (brain-side) OXC levels as compared to control. Oxcarbazepine nuclear receptor subfamily 3 group C member 1 Homo sapiens
2 GR EPI-EC silencing or inhibition led to (1) increased Pphenytoin BBB permeability as compared to control; (2) decreased CYP function, indirectly evaluated by resorufin formation; (3) improved OXC bioavailability with increased abluminal (brain-side) OXC levels as compared to control. Oxcarbazepine nuclear receptor subfamily 3 group C member 1 Homo sapiens