Title : Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1.

Pub. Date : 2018 Dec

PMID : 30261753






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Stimulation by cytokines, growth factors, and hormones triggers this activation by phosphorylating STAT3 at tyrosine 705. Tyrosine signal transducer and activator of transcription 3 Homo sapiens
2 Further assays showed that the reduction effects of compound 16 on tyrosine 705 of STAT3 were attributed to up-regulation of protein tyrosine phosphatase SHP-1. Tyrosine signal transducer and activator of transcription 3 Homo sapiens