Title : Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity.

Pub. Date : 2018

PMID : 30254491






2 Functional Relationships(s)
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1 Palbociclib is a putative novel DIPG treatment that restricts the proliferation of rapidly dividing cancer cells via selective inhibition of cyclin-dependent kinase (CDK) 4 and CDK6. Dipinacoline glutamate cyclin dependent kinase 4 Homo sapiens
2 Conclusion: These data illustrate the in vitro antiproliferative effects of CDK4/6 and mTOR inhibitors in DIPG cells. Dipinacoline glutamate cyclin dependent kinase 4 Homo sapiens