Pub. Date : 2018
PMID : 30246635
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Circadian PER2 Enhancer Nobiletin Reverses the Deleterious Effects of Midazolam in Myocardial Ischemia and Reperfusion Injury. | Midazolam | period circadian clock 2 | Mus musculus |
| 2 | Unexpectedly, only midazolam treatment resulted in an immediate and significant downregulation of Per2 transcript levels. | Midazolam | period circadian clock 2 | Mus musculus |
| 3 | Using the recently identified flavonoid, nobiletin, as a PER2 enhancer completely abolished the deleterious effects of midazolam during myocardial IR-injury. | Midazolam | period circadian clock 2 | Mus musculus |
| 4 | CONCLUSION: We identified midazolam mediated downregulation of cardiac PER2 as an underlying mechanism for a deleterious effect of midazolam pretreatment in myocardial IR-injury. | Midazolam | period circadian clock 2 | Mus musculus |
| 5 | CONCLUSION: We identified midazolam mediated downregulation of cardiac PER2 as an underlying mechanism for a deleterious effect of midazolam pretreatment in myocardial IR-injury. | Midazolam | period circadian clock 2 | Mus musculus |
| 6 | These findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancers nobiletin or tangeritin as a preventative therapy for myocardial IR-injury in the perioperative setting where midazolam pretreatment occurs frequently. | Midazolam | period circadian clock 2 | Mus musculus |