Title : Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Pub. Date : 2018 Dec 4

PMID : 30244971






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The mTORC1/4E-BP axis regulates aspartate, asparagine, and serine synthesis by modulating mRNA translation, while ablation of 4E-BP1/2 substantially decreases sensitivity of breast cancer and melanoma cells to KI/biguanide combinations. Serine CREB regulated transcription coactivator 1 Mus musculus