Title : The role of serotonin and its receptors on the anticonvulsant effect of curcumin in pentylenetetrazol-induced seizures.

Pub. Date : 2018 Oct 15

PMID : 30243647






1 Functional Relationships(s)
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1 SIGNIFICANCE: According to these results, it may be suggested that curcumin exerts anticonvulsive effects by increasing the serotonin levels in the brain that influence receptors, including 5-HT1A, 5-HT2C, and 5-HT4 and likely through the reduction of 5-HT7 gene expression. Serotonin 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus