Title : Chalcone Derivatives 4'-Amino-1-Naphthyl-Chalcone (D14) and 4'-Amino-4-Methyl-1-Naphthyl-Chalcone (D15) Suppress Migration and Invasion of Osteosarcoma Cells Mediated by p53 Regulating EMT-Related Genes.

Pub. Date : 2018 Sep 19

PMID : 30235848






2 Functional Relationships(s)
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1 These effects probably result from the induced increase of p53 protein expression by the two chalcones. Chalcones tumor protein p53 Homo sapiens
2 In conclusion, chalcones D14 and D15 have potential anti-metastatic activity mediated by p53 that can be exploited for OS treatment. Chalcones tumor protein p53 Homo sapiens