Title : Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice.

Pub. Date : 2018

PMID : 30235452






2 Functional Relationships(s)
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1 Fisetin treatment also reduced liver lipid droplet and hepatocyte steatosis, alleviated serum free fatty acid, and leptin concentrations, significantly decreased fatty acid synthase, and significantly increased phosphorylation of AMPKalpha and the production of sirt-1 and carnitine palmitoyltransferase I in the liver tissue. fisetin sirtuin 1 Mus musculus
2 CONCLUSION: This study suggests that fisetin is a potential novel treatment for alleviating hepatic lipid metabolism and improving NAFLD in mice via activation of the sirt1/AMPK and beta-oxidation pathway. fisetin sirtuin 1 Mus musculus