Title : ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.

Pub. Date : 2018 Sep 20

PMID : 30220454






1 Functional Relationships(s)
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1 We now show that caspase-2, whose expression is ER-stress inducible and elevated in human and mouse NASH, controls the buildup of hepatic-free cholesterol and triglycerides by activating sterol regulatory element-binding proteins (SREBP) in a manner refractory to feedback inhibition. Triglycerides caspase 2 Homo sapiens