Pub. Date : 2019 Jan
PMID : 30201289
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While these canonical cytoplasmic roles of malonyl-CoA have been well described, malonyl-CoA can also be generated within the mitochondrial matrix by an alternative pathway: the ATP-dependent ligation of malonate to Coenzyme A by the malonyl-CoA synthetase ACSF3. | Malonyl Coenzyme A | acyl-CoA synthetase family member 3 | Homo sapiens |
| 2 | While these canonical cytoplasmic roles of malonyl-CoA have been well described, malonyl-CoA can also be generated within the mitochondrial matrix by an alternative pathway: the ATP-dependent ligation of malonate to Coenzyme A by the malonyl-CoA synthetase ACSF3. | Malonyl Coenzyme A | acyl-CoA synthetase family member 3 | Homo sapiens |
| 3 | A major role for ACSF3 is to provide a metabolic pathway for the clearance of malonate by the generation of malonyl-CoA, which can then be decarboxylated to acetyl-CoA by malonyl-CoA decarboxylase. | Malonyl Coenzyme A | acyl-CoA synthetase family member 3 | Homo sapiens |
| 4 | Additionally, ACSF3-derived malonyl-CoA can be used to malonylate lysine residues on proteins within the matrix of mitochondria, possibly adding another regulatory layer to post-translational control of mitochondrial metabolism. | Malonyl Coenzyme A | acyl-CoA synthetase family member 3 | Homo sapiens |
| 5 | The discovery of ACSF3-mediated generation of malonyl-CoA defines a new mitochondrial metabolic pathway and raises new questions about how the metabolic fates of this multifunctional metabolite intersect with mitochondrial metabolism. | Malonyl Coenzyme A | acyl-CoA synthetase family member 3 | Homo sapiens |