Title : Bridging Cancer Biology with the Clinic: Comprehending and Exploiting IDH Gene Mutations in Gliomas.

Pub. Date : 2018 Sep-Oct

PMID : 30194083






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 IDH1 and IDH2 mutations are restricted to specific arginine residues in the active site of the enzymes and are gain-of-function, i.e. they confer a neomorphic enzyme activity resulting in the accumulation of D-2-hydroxyglutarate (2-HG). Arginine isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens