Pub. Date : 2018 Sep-Oct
PMID : 30194083
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IDH1 and IDH2 mutations are restricted to specific arginine residues in the active site of the enzymes and are gain-of-function, i.e. they confer a neomorphic enzyme activity resulting in the accumulation of D-2-hydroxyglutarate (2-HG). | Arginine | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |