Pub. Date : 2018 Sep 4
PMID : 30181526
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways. | Cholesterol | NPC intracellular cholesterol transporter 2 | Homo sapiens |
| 2 | The formation of a NPC1-NPC2 protein-protein complex is believed to be necessary for the transfer of cholesterol and lipids out of the late endosomal (LE)/lysosomal (Lys) compartments. | Cholesterol | NPC intracellular cholesterol transporter 2 | Homo sapiens |
| 3 | Mutations in either NPC1 or NPC2 can lead to an accumulation of cholesterol and lipids in the LE/Lys, the primary phenotype of the NPC disease. | Cholesterol | NPC intracellular cholesterol transporter 2 | Homo sapiens |
| 4 | Based on the results, we propose that, depending on the location of the cholesterol ligand, a dynamical interface between the NPC2 and NPC1(NTD) proteins exists. | Cholesterol | NPC intracellular cholesterol transporter 2 | Homo sapiens |
| 5 | Structural features of a particular interface can lower the energy barrier and stabilize the passage of the cholesterol substrate from NPC2 to NPC1(NTD). | Cholesterol | NPC intracellular cholesterol transporter 2 | Homo sapiens |