Title : CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates.

Pub. Date : 2018 Sep 5

PMID : 30176535






1 Functional Relationships(s)
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1 The clofarabine-containing compound (2) was shown to be more potent than APCP with IC50 values of 0.18 muM (vs. 3.8 muM) on purified protein and 0.24 muM (vs. 23.6 muM) on CD73 expressed on cells. Clofarabine 5'-nucleotidase ecto Homo sapiens