Title : Synthesis and SAR of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as potent and selective CDK4/6 inhibitors.

Pub. Date : 2018 Sep 5

PMID : 30165341






1 Functional Relationships(s)
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1 The compound showed good anti-proliferative activity when tested in a panel of tumor cell lines with CDK4/6 related mechanism of action, the results clearly suggest that compound 13n works much better than Ly2385219 which is a selective CDK4/6 inhibitor. abemaciclib cyclin dependent kinase 4 Homo sapiens