Title : Relationships between cyclic AMP levels and lipolysis in fat cells after isoproterenol and forskolin stimulation.

Pub. Date : 1986 Aug

PMID : 3016246






7 Functional Relationships(s)
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1 The maximum responses to isoproterenol for both cAMP accumulation and glycerol release were increased by the presence of either adenosine deaminase or theophylline. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens
2 Under these conditions, high concentrations of isoproterenol continued to increase cAMP accumulation while having no further effect on lipolysis. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens
3 These results support the concept that the maximum response to isoproterenol alone was limited by the accumulation of cAMP within the cells. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens
4 The maximum response to isoproterenol in the presence of either theophylline or adenosine deaminase (and to forskolin) was limited by some step in the lipolytic process distal to cAMP accumulation. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens
5 The relationships between cAMP levels and lipolysis for isoproterenol and forskolin were found to be different. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens
6 A 6-fold increase in cAMP levels was sufficient to maximally increase lipolysis with isoproterenol, whereas the maximum lipolytic response to forskolin was associated with a 20-fold increase in cAMP levels. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens
7 At any given concentration of cAMP the corresponding lipolytic response was greater for isoproterenol than for forskolin. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens