Title : Novel therapeutic roles of MC-4 in combination with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of rapamycin complex 1 pathways.

Pub. Date : 2018 Oct

PMID : 30160042






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Everolimus led to compensatory Akt activation by inhibiting only mTORC1 signaling pathway. Everolimus CREB regulated transcription coactivator 1 Mus musculus
2 The synergistic antitumor and anti-metastatic effects induced by co-administration of MC-4 and everolimus involve cell growth inhibition and autophagic cell death via dual targeting of phosphatidylinositol 3-kinase (PI3K)/Akt/PKM2 and mTORC1. Everolimus CREB regulated transcription coactivator 1 Mus musculus