Title : ADP sensitizes ZL55 cells to the activity of cisplatin.

Pub. Date : 2019 Apr

PMID : 30144378






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Both ADP and cisplatin increased p53 protein, but ADP was also able to enhance p53 messenger RNA. Cisplatin tumor protein p53 Homo sapiens
2 Both ADP and cisplatin increased p53 protein, but ADP was also able to enhance p53 messenger RNA. Cisplatin tumor protein p53 Homo sapiens
3 P53 silencing resulted in a very large decrement of cell death induced by ADP or by cisplatin and reverted ADP effects on mTOR/S6K phosphorylation, suggesting that activated p53 may act as a negative regulator of mTOR. Cisplatin tumor protein p53 Homo sapiens
4 P53 silencing resulted in a very large decrement of cell death induced by ADP or by cisplatin and reverted ADP effects on mTOR/S6K phosphorylation, suggesting that activated p53 may act as a negative regulator of mTOR. Cisplatin tumor protein p53 Homo sapiens