Pub. Date : 2018 Aug
PMID : 30128699
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intravenous meropenem/vaborbactam (Vabomere ) is the first carbapenem/beta-lactamase inhibitor combination approved in the USA for use in patients with complicated urinary tract infections (cUTIs), including pyelonephritis. | Meropenem | beta-lactamase | Klebsiella pneumoniae |
| 2 | Vaborbactam is a potent inhibitor of class A serine carbapenemases, which, when combined with the antibacterial meropenem, restores the activity of meropenem against beta-lactamase producing Enterobacteriaceae, particularly Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. | Meropenem | beta-lactamase | Klebsiella pneumoniae |
| 3 | Vaborbactam is a potent inhibitor of class A serine carbapenemases, which, when combined with the antibacterial meropenem, restores the activity of meropenem against beta-lactamase producing Enterobacteriaceae, particularly Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. | Meropenem | beta-lactamase | Klebsiella pneumoniae |
| 4 | Meropenem/vaborbactam demonstrated excellent in vitro activity against Gram-negative clinical isolates, including KPC- and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. | Meropenem | beta-lactamase | Klebsiella pneumoniae |