Pub. Date : 2018 Sep 18
PMID : 30126633
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tannic acid inhibits NLRP3 inflammasome-mediated IL-1beta production via blocking NF-kappaB signaling in macrophages. | Tannins | interleukin 1 beta | Homo sapiens |
| 2 | Here, we reported that tannic acid inhibited NLRP3 inflammasome activation by blocking NF-kappaB signaling to suppress IL-1beta secretion. | Tannins | interleukin 1 beta | Homo sapiens |
| 3 | We found that the BMDMs (bone marrow-derived macrophages cells) pre-treated with tannic acid blocked caspase-1 cleavage and inhibited IL-1beta secretion in a NLRP3-dependent manner, and suppressed NF-kappaB signaling activation by inhibiting NF-kappaB/P65 nuclear localization, suggesting that tannic acid inhibited NLRP3 inflammasome activation. | Tannins | interleukin 1 beta | Homo sapiens |