Title : Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes.

Pub. Date : 2018 Dec

PMID : 30113702






1 Functional Relationships(s)
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1 We previously showed that (+)-tramadol is metabolized in dog liver to (+)-M1 exclusively by CYP2D15 and to (+)-M2 by multiple CYPs, but primarily CYP2B11. Tramadol cytochrome P450 2B11 Canis lupus familiaris